Human Sera
Cayman Chemical Suplatstosylate 50mg
An inhibitor of amyloid-B aggregation inhibits aggregation of monomeric AB42 and induces disaggregation of AB42 fibrils in vitro from 3 1-50 UM reduces AB42-induced toxicity in HT22 cells at 10 UM increases step-through latency in a passive avoidance test and increases spontaneous alteration in the Y-maze compared with vehicle control mice in a mouse model of AB42-induced acute Alzheimers disease at 10 mg/kg decreases brain levels of AB42 and increases spontaneous alteration in the Y-maze in the APP/PS1 transgenic mouse model of Alzheimers disease
Cayman Chemical ClInofIbrate 50mg
A caspase-1 fluorogenic substrate upon enzymatic cleavage AMC is released and its fluorescence can be used to quantify enzyme activity ex/em 340-360/440-460 nm respectively
Cayman Chemical ResorufInsodIum salt 100mg
A chromene with anti-juvenile hormone activity inhibits juvenile hormone biosynthesis in isolated spontaneously active cockroach corpora allata at 1 mM inhibits development of the corpus allatum in newly eclosed female milkweed bugs and causes allatal regression when applied 120 hours post-eclosion in normally developing females at 8 g/cm2 as a coating in Petri dish induces precocious metamorphosis in milkweed bug second-stage nymphs when applied as a coating to Petri dishes at 0 4 and 0 7 g/cm2 inhibits ovarian development in various insects including milkweed bugs cotton stainers apple maggots and Mexican bean beetles inhibits production of the trichothecene mycotoxin 3-ADON in F graminearum (IC50 1 2 M) without inhibiting fungal growth
Cayman Chemical AcetylDLcarnItInchLRIde 50mg
For screening a variety of immuno-oncology associated compounds contains more than 90 cancer and immunology-associated compounds as 10 mM stock solutions in DMSO includes a variety of immuno-oncology target modulators including but not limited to adenosine CCR CXCR and TLR agonists and antagonists BTK PI3K and BRAF inhibitors PD-1/PD-L1 interaction inhibitors and HDAC inhibitors
Cayman Chemical StrontIum Rnlate 50mg
A pyranone with antifungal and insecticidal activities active against a laboratory strain and clinical isolates of C albicans (MICs 49 and 12-97 Ug/ml respectively) reduces fungal load in the vagina in a mouse model of fluconazole-resistant vulvovaginal candidiasis at 1 2 and 4 mg/kg per day topically or 20 40 and 80 mg/kg per day orally toxic to S exigua and S litura larvae with LC50 values of 545 61 and 986 88 mg/L for dietary administration and 519 48 and 1041 42 mg/L for contact application
Cayman Chemical NomIfensIn 100mg
A triacylglycerol dietary administration reduces hepatic triglyceride and cholesterol levels in mice at 30 g/kg
Cayman Chemical AlarelInacetate 50mg
A dual-site covalent antagonist of PPARY inhibits MRL20-induced allosteric activation of PPARY in a reporter assay using HEK293T cells at 5 M reduces basal activity of PPARY and inhibits binding of DHA to PPARY in a TR-FRET assay
Cayman Chemical DIhydrophytol 100mg
An intermediate in the biosynthesis of CoA from pantothenic acid phosphorylated by CoA synthase in humans to form CoA can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription
Cayman Chemical 13 E-DocosenoIc AcId 50mg
A semisynthetic echinocandin antifungal inhibits 13-b-D glucan synthase from several C albicans clinical isolates (IC50s 0 89-7 96 ng/ml for the wild-type enzyme) active against C albicans C parapsilosis C tropicalis and C guiillermondi (MICs 0 03-4 Ug/ml) and A fumigatus (MIC90 0 03 Ug/ml) increases survival and decreases the severity of pulmonary lesions in A fumigatus-infected neutropenic rabbits at 10 mg/kg
Cayman Chemical 7Deaza7Iodo2deoxygunos 50mg
A cationic lipid transfection of liposomes containing DOSPA and encapsulating plasmid DNA encodingBgal increaseBgal activity in NIH3T3 cells
Cayman Chemical RucaparIbcamsylate 50mg
An ionizable cationic lipid has been used in combination with other lipids for the formation of LNPs immunization with SARS-CoV-2 spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice administration of mRNA encoding B7-H3 X CD3 BiTE antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models
Cayman Chemical Esaxerenon 100mg
A diterpenoid with diverse biological activities a hydrolysis product of stevioside scavenges hydroxyl and superoxide radicals in cell-free assays (IC50s 76.92 and 91.7 Ug/ml respectively) inhibits DNA polymerase a B and λ as well as topoisomerase II (IC50s 64 177 103 and 190 UM respectively) active against various bacteria and fungi (MICs 8-250 and 62.5-500 Ug/ml Ug/ml respectively) induces relaxation of isolated rat aortic strips precontracted with vasopressin an effect that can be reversed by glibenclamide or apamin but not charybdotoxin reduces plasma glucose levels in the intravenous glucose tolerance test in Zucker diabetic rats at 5 and 10 mg/kg has been used in the synthesis of isosteviol glycosides with anticancer activity
Cayman Chemical LomerIzInhydrochlorIde 100mg
A potent Nampt inhibitor (IC50 3 1 nM) selective for Nampt over a panel of 100 human kinases at 1 M inhibits NAD formation in and proliferation of HCT116 cells (IC50s 1 8 and 8 9 nM respectively) inhibits cell growth in a panel of cancer cell lines (IC50s formation in an A2780 ovarian carcinoma mouse xenograft model (ED50 2 mg/kg)
Cayman Chemical LumIracoxIb 100mg
A TRPV4 antagonist (IC50s 2 3 5 9 and 3 2 UM for human mouse and rat respectively) selective for TRPV4 over TRPV1 TRPV3 and TRPM8 (IC50s 100 30 and 30 UM respectively) reduces GSK1016790A-induced increases in IGly from 34 5 to 0 97 in mouse hippocampal neurons in vitro (10 UM) blocks GSK1016790A-induced arteriolar dilation and increases myogenic tone in rat cremaster arterioles ex vivo (30 UM) reduces edema and MAPK signaling induced by traumatic brain injury in rats (1 mg/kg i p ) inhibits breakdown of the blood-retinal barrier in streptozotocin-induced diabetic rats (100 UM)